Posted: March 21st, 2023

Sickle cell disease is an adaptive response against malaria

Disorders Of Erythrocyte Function 1.Sickle cell disease is an adaptive response against malaria. Ace my homework – Write my paper – Online assignment help tutors – Discuss and identify the pathogen and transmission of malaria.

2. Where and why do you think an adaptation occurred that led to the development of sickle cell disease and what is the pathophysiology of the adaptation?

3. Why do people who no longer live in parts of the world where malaria is prevalent still develop sickle cell disease and how and why does it occur?

4.How can we advise families with this debilitating disease?

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According to a study published in the Journal of Immunology Research, sickle cell disease is an adaptive response to malaria. Malaria is a parasitic infection caused by Plasmodium species, which are transmitted to humans through the bites of infected female Anopheles mosquitoes. The disease is prevalent in sub-Saharan Africa, parts of Asia, and South America. The pathogen that causes malaria is a single-celled parasite belonging to the genus Plasmodium, with P. falciparum being the most deadly species (Iwalokun et al., 2019: 2024 – Online Assignment Homework Writing Help Service By Expert Research Writers).

Sickle cell disease is more prevalent in populations that live in areas with a high incidence of malaria, such as sub-Saharan Africa, Southeast Asia, and the Mediterranean. The sickle cell trait is a genetic adaptation that evolved in response to malaria. The sickle cell gene (HbS) is a mutation in the beta-globin gene of hemoglobin, which causes red blood cells to form a sickle shape. In individuals with the sickle cell trait, red blood cells are less susceptible to invasion by the malaria parasite, and this provides a survival advantage against the disease. The pathophysiology of sickle cell disease results from the abnormal shape of the red blood cells, which can obstruct small blood vessels, causing tissue damage and pain. A study published in the Annals of the New York Academy of Sciences suggests that the sickle cell mutation may have arisen in regions with high malaria prevalence because it confers protection against malaria while having a minimal impact on survival (Gong et al., 2018: 2024 – Write My Essay For Me | Essay Writing Service For Your Papers Online).

People who no longer live in parts of the world where malaria is prevalent can still develop sickle cell disease if they inherit the sickle cell gene from their parents. The inheritance pattern of sickle cell disease is autosomal recessive, meaning that a person must inherit two copies of the HbS gene (one from each parent) to develop the disease. If a person inherits only one copy of the gene, they have the sickle cell trait, but are usually asymptomatic. The persistence of the sickle cell gene in populations that no longer face a high risk of malaria is due to the fact that carriers of the sickle cell trait have a survival advantage against malaria. However, as populations move away from malaria-endemic areas, the frequency of the HbS gene decreases over time (Gong et al., 2018: 2024 – Write My Essay For Me | Essay Writing Service For Your Papers Online).

Families affected by sickle cell disease need to receive comprehensive care and support to manage the symptoms and complications of the disease. Genetic counseling is an essential component of the care plan, as it helps families to understand the inheritance pattern of the disease and to make informed decisions about family planning. Treatment options for sickle cell disease include blood transfusions, hydroxyurea therapy, and bone marrow transplantation. Patients with sickle cell disease also need to receive routine vaccinations, prophylactic antibiotics, and regular monitoring of their blood counts and organ function to prevent and manage complications such as infections, stroke, and organ damage. It is crucial to provide families with education and resources to help them cope with the physical, emotional, and financial impact of sickle cell disease. A review article published in the Journal of Clinical Medicine suggests that a multidisciplinary approach to sickle cell disease management, involving primary care physicians, hematologists, and other specialists, is essential for improving outcomes (Puri et al., 2020).

In my opinion, sickle cell disease is a fascinating example of how evolutionary pressures can shape human genetic diversity. The interaction between the sickle cell gene and malaria has been studied extensively, and it highlights the complex interplay between genetics and infectious diseases. However, it is important to remember that sickle cell disease is a serious and

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