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Posted: July 13th, 2022
Cancer cells are fast growing and have increased survival rates and proliferation. In order to do this they rewire their metabolism and increase glucose uptake, glycolysis and lactic acid fermentation. This happens even under aerobic conditions, when mitochondria are functioning normally and is called the Warburg effect. For some background reading see e.g. Liberti, M. V., & Locasale, J. W. (2016). The Warburg Effect: How Does it Benefit Cells?. Trends in biochemical sciences, A prominent role in glucose homeostasis is played by glucose transport and the glucose transporters and the hormone insulin.
In the past years it has been shown that epigenetic mechanisms, and more specifically the effects of micro-RNAs (miRNAs) have a large influence on glucose homeostasis and also on the Warburg effect. See e.g. the following mini review Li, H-J., & Chen, W. (2014). Role of MicroRNAs in the Warburg Effect and Mitochondrial Metabolism in Cancer. Asian Pacific Journal of Cancer prevention, 15, 7015-7019 Your assignment should focus on the role of miRNAs in the Warburg effect.
However, this is not an assignment on the functions and processing of micro-RNAs; Just on their actions and effects in the cell biological process of glucose homeostasis. You will also be able to find a lot of information if you would do a literature search into MicroRNAs and Type 2 Diabetes Mellitus (T2DM) or glucose homeostasis. The goal of this assignment is for you to obtain detailed understanding of one or more cell biological processes and the importance of microRNAs in modulating these processes. Biology Assignment: I need help writing a research paper.
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